Dr. Engle talks about the sadly very different stories of his siblings, the factors that affect neurological resiliency, the need for establishing neurological performance baselines for athletes, the science behind CBD being a neuro-protectant, the safety and efficacy of psilocybin, how scaling research can dilute data, the importance of dipping one’s toes into non-ordinary states of consciousness before trying psychedelics, how we seem to have hit a new phase of learning more about preparation, and how not trying to achieve transcendence is suppressing a biological need.